Precision Pain Pipeline:
The Doloromics pipeline is built upon our proprietary discovery and validation platform DOLOReS. Through our human-first approach, we are ensuring that we prosecute targets directly implicated by data derived from human pain patients and the mechanistic signatures driving their condition. This has already led to multiple exciting, high-value programs expected to precisely address a broad spectrum of human pain states.
Precision Pain Pipeline:
Program
Program
Preclinical
Hit ID
Lead Gen.
Lead Opt.
IND Enablement
Phase 1
Phase 2
Indication
Indication
Dolo-5.1
Dolo-5.1
58
GPCR
Small Molecule
Preclinical
Hit ID
Lead Gen.
Lead Opt.
IND Enablement
Phase 1
Phase 2
Migraine
Migraine
Dolo-3.1
Dolo-3.1
58
Protein Kinase
Small Molecule
Preclinical
Hit ID
Lead Gen.
Lead Opt.
IND Enablement
Phase 1
Phase 2
CIPN
CIPN
Dolo-4.2
Dolo-4.2
35
GPCR
Small Molecule
Preclinical
Hit ID
Lead Gen.
Lead Opt.
IND Enablement
Phase 1
Phase 2
Neuroprotection
Neuroprotection
Dolo-2.1
Dolo-2.1
21
Growth Factor
Monoclonal Antibody
Preclinical
Hit ID
Lead Gen.
Lead Opt.
IND Enablement
Phase 1
Phase 2
OA/RA
OA/RA
Dolo-1.1
Dolo-1.1
15
Cytokine
Monoclonal Antibody
Preclinical
Hit ID
Lead Gen.
Lead Opt.
IND Enablement
Phase 1
Phase 2
Oncology Pain
Oncology Pain
Dolo-0.2
Dolo-0.2
15
Ion Channel Auxiliary Protein
Small Molecule
Preclinical
Hit ID
Lead Gen.
Lead Opt.
IND Enablement
Phase 1
Phase 2
Small Fiber Neuropathy
Small Fiber Neuropathy
Dolo-0.1
Dolo-0.1
15
Cytokine
Monoclonal Antibody
Preclinical
Hit ID
Lead Gen.
Lead Opt.
IND Enablement
Phase 1
Phase 2
Fibromyalgia
Fibromyalgia
